Electroanalytical sensors-based biogenic synthesized metal oxide nanoparticles for potentiometric assay of pantoprazole sodium

Two modified coated membrane sensors were designed and tested. Pantoprazole-phosphotungstate was prepared by a reaction of pantoprazole with phosphotungstic acid in the solvent mediator o-nitrophenyloctyl ether. metal oxide nanoparticles nickel iron nanoparticles, synthesized from green sources Matricaria recutita flowers Salvia officinalis leaves extracts, respectively. These used for potentiometric assay sodium authentic sample commercial products. The results showed that improved nanosensors exhibited linearity using concentration range 1.0 × 10−9–1.0 10−2 10−10–1.0 mol L−1, respectively compared 10−6–1.0 L−1 normally sensor. lower limits detection (7.6 10−6, 2.3 10−10, 2.8 10−11 L−1) quantification (1.0 10−9, 10−10 determined each three proposed sensors. Least squares calculations gave EmV = (27.266 ± 0.5) log (pantoprazole) + 433.37, (30.967 0.3) 432.24 enriched nano-metal oxides, (26.642 0.6) 443.69 conventional type, correlation coefficients around 0.999 accuracy precision systems estimated excellent validity suitability determination an sample.